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Merck
CN

SML0708

BMS-182874 hydrochloride

≥98% (HPLC)

Synonym(s):

5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide hydrochloride, BMS182874, N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O3S · HCl
CAS Number:
1215703-04-0
Molecular Weight:
381.88
UNSPSC Code:
12352202
NACRES:
NA.77

Key Documents

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Product Name

BMS-182874 hydrochloride, ≥98% (HPLC)

InChI

1S/C17H19N3O3S.ClH/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4;/h5-10,19H,1-4H3;1H

InChI key

UZZFRNZGYDOBAO-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

BMS-182874 is a potent selective nonpeptide endothelin ETA receptor antagonist.
BMS-182874 is a potent selective nonpeptide endothelin ETA receptor antagonist. BMS-182874 is 1000-fold selective for ETA over ETA B receptors with a Ki of 48 nM for ETA receptors vs >50 μM for ETB.

Features and Benefits

This compound is featured on the Endothelin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
053M4612V

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