Skip to Content
Merck
CN

SML0684

SF1670

≥98% (HPLC)

Synonym(s):

N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C19H17NO3
CAS Number:
345630-40-2
Molecular Weight:
307.34
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, light pink to red to very dark purple

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(c1cc2c(cc1)c3c(cccc3)C(=O)C2=O)C(=O)C(C)(C)C

InChI

1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChI key

VZQDDSYKVYARDW-UHFFFAOYSA-N

Related Categories

Application

SF1670 has been used:
  • To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
  • To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
  • To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

Biochem/physiol Actions

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000192434
0000167428
0000153376
0000153376
0000192434

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN.
Zhong B, et al.
BMC Medical Genomics, 10(1), 64-64 (2017)
Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis.
Choi J, et al.
Reproduction (Cambridge, England), 153(1), 11-21 (2017)
Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
Ryu J W, et al.
Oncotarget, 8(3), 4181-4181 (2017)
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.
Christie K J, et al.
The Journal of Neuroscience, 30(27), 9306-9315 (2010)
Stefanie Kälin et al.
Cell metabolism, 26(3), 475-492 (2017-09-07)
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service