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N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide
C19H17NO3
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
, light pink to red to very dark purple
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
InChI key
VZQDDSYKVYARDW-UHFFFAOYSA-N
Application
SF1670 has been used:
- To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
- To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
- To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.
Biochem/physiol Actions
PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN.
BMC Medical Genomics, 10(1), 64-64 (2017)
Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
Oncotarget, 8(3), 4181-4181 (2017)
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.
The Journal of Neuroscience, 30(27), 9306-9315 (2010)
Cell metabolism, 26(3), 475-492 (2017-09-07)
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3
Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis.
Reproduction (Cambridge, England), 153(1), 11-21 (2017)
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