All Photos(1)
Synonym(s):
2-Chloro-N-[[2′-[(cyanoamino)sulfonyl][1,1′-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide
Empirical Formula (Hill Notation):
C29H24ClN3O3S
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C29H24ClN3O3S/c1-21-10-12-22(13-11-21)18-33(29(34)26-7-2-4-8-27(26)30)19-23-14-16-24(17-15-23)25-6-3-5-9-28(25)37(35,36)32-20-31/h2-17,32H,18-19H2,1H3
InChI key
ITDBPOSLOROLMT-UHFFFAOYSA-N
Biochem/physiol Actions
S0859 helps to prevent the depolarization-induced alkalinization (DIA) in astrocytes.
S0859 is a selective high-affinity generic inhibitor of the Na+/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na+-H+ exchange (NHE).
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 4
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The Na+/HCO3? co-transporter is protective during ischemia in astrocytes.
Yao H, et al.
Neuroscience, 339, 329-337 (2016)
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