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Key Documents

SML0631

Sigma-Aldrich

NE-100

≥98% (HPLC)

Synonym(s):

4-Methoxy-3-(2-phenylethoxy)-N,N-dipropyl-benzeneethanamine hydrochloride, N,N-Di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H33NO2 · HCl
CAS Number:
149409-57-4
Molecular Weight:
391.97
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 15 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C21H29NO2.ClH/c1-4-22(5-2)15-13-19-11-12-20(23-3)21(17-19)24-16-14-18-9-7-6-8-10-18;/h6-12,17H,4-5,13-16H2,1-3H3;1H

InChI key

LPMIMPZUXJWRJJ-UHFFFAOYSA-N

Biochem/physiol Actions

NE-100 is a potent and selective σ1 receptor antagonist with an IC50 value of 1.54 +/- 0.26 nM for σ1 receptors, > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000036388
0000036389
023M4623V

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Md Shenuarin Bhuiyan et al.
European journal of pharmacology, 650(2-3), 621-628 (2010-11-04)
In the present study, we investigated the vasculoprotective effect of sigma-1 receptor stimulation with fluvoxamine on pressure overload hypertrophy-induced vascular injury in the thoracic aorta and defined mechanisms underlying that activity. Wistar rats underwent bilateral ovariectomy, and two weeks later
Tamaki Ishima et al.
Progress in neuro-psychopharmacology & biological psychiatry, 32(7), 1656-1659 (2008-07-24)
In addition to acetylcholinesterase (AChE) inhibition, donepezil binds to sigma-1 receptors. In this study, we examined the effects of donepezil on nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Donepezil significantly potentiated the NGF-induced neurite outgrowth in a concentration-dependent
José Manuel Entrena et al.
Pain, 143(3), 252-261 (2009-04-21)
We evaluated the role of sigma(1) receptors on capsaicin-induced mechanical hypersensitivity and on nociceptive pain induced by punctate mechanical stimuli, using wild-type and sigma(1) receptor knockout (sigma(1)-KO) mice and selective sigma(1) receptor-acting drugs. Mutation in sigma(1)-KO mice was confirmed by
Matthew J Robson et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22(4), 308-317 (2011-09-14)
Ketamine is an NMDA antagonist and dissociative anesthetic that has been shown to display rapid acting and prolonged antidepressant activity in small-scale human clinical trials. Ketamine also binds to σ receptors, which are believed to be protein targets for a
Kenji Hashimoto et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32(3), 514-521 (2006-02-24)
This study was undertaken to examine the effects of the selective serotonin reuptake inhibitors fluvoxamine and paroxetine on cognitive deficits in mice after repeated administration of the N-methyl-D-aspartate receptor antagonist phencyclidine (PCP). In the novel object recognition test, repeated administration
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