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Key Documents

SML0627

Sigma-Aldrich

ML-SA1

≥95% (HPLC), powder, TRPML channel agonist

Synonym(s):

1-[(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]-1,2,3,4-tetrahydro-2,2,4-trimethyl-quinoline, 2-(2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl)isoindoline-1,3-dione, Mucolipin Synthetic Agonist 1

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25 MG
CN¥1,303.87

CN¥1,303.87

List PriceCN¥1,955.82Save 33%

Estimated to ship onApril 27, 2025Details

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25 MG
CN¥1,303.87

About This Item

Empirical Formula (Hill Notation):
C22H22N2O3
CAS Number:
332382-54-4
Molecular Weight:
362.42
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥1,303.87

List PriceCN¥1,955.82Save 33%

Estimated to ship onApril 27, 2025Details

Request a Bulk Order

Product Name

ML-SA1, ≥95% (HPLC)

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

N3(C(=O)c4c(cccc4)C3=O)CC(=O)N1C(CC(c2c1cccc2)C)(C)C

InChI

1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3

InChI key

KDDHBJICVBONAX-UHFFFAOYSA-N

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Show Differences

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ML-SA1 ≥95% (HPLC)

SML0627

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IQ-1 ≥95% (HPLC)

SML1147

IQ-1

L-152,804 ≥98% (HPLC)

SML0891

L-152,804

Tanaproget ≥98% (HPLC)

SML2779

Tanaproget

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

yellow to orange

color

white to beige

color

white to beige

Application

ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.[1]

Biochem/physiol Actions

ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.
ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000250058
    0000250058
    0000173913
    0000173913
    0000346457

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    Gastric acid secretion from parietal cells is mediated by a Ca2+ efflux channel in the tubulovesicle.
    Sahoo N, et al.
    Developmental Cell, 41(3), 262-273 (2017)
    Hongyan Yu et al.
    British journal of cancer, 125(10), 1420-1431 (2021-09-23)
    Prostate cancer (Pca) is the most common cancer type among males worldwide. Dysregulation of Ca2+ signaling plays important roles during Pca progression. However, there is lack of information about the role of endolysosomal Ca2+ -permeable channels in Pca progression. The
    Dengqin Zhong et al.
    Nature communications, 14(1), 3997-3997 (2023-07-07)
    Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose. However, the roles of lysosomes in U decorporation and detoxification remain to be elucidated. Mucolipin
    Dale P Corkery et al.
    EMBO reports, 24(9), e56841-e56841 (2023-06-29)
    Lysosomal membrane damage represents a threat to cell viability. As such, cells have evolved sophisticated mechanisms to maintain lysosomal integrity. Small membrane lesions are detected and repaired by the endosomal sorting complex required for transport (ESCRT) machinery while more extensively
    Lalit Pukhrambam Singh et al.
    Diseases (Basel, Switzerland), 9(4) (2021-12-24)
    Chronic hyperglycemia-induced thioredoxin-interacting protein (TXNIP) expression, associated oxidative/nitrosative stress (ROS/RNS), and mitochondrial dysfunction play critical roles in the etiology of diabetic retinopathy (DR). However, there is no effective drug treatment to prevent or slow down the progression of DR. The
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