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Merck
CN

SML0523

ISPA-28

≥98% (HPLC)

Synonym(s):

N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-(1-ethyl-3-methyl-1H-pyrazol-4-yl)-4,5-dihydro-5-Isoxazolecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C21H24N6O3
CAS Number:
1006335-39-2
Molecular Weight:
408.45
UNSPSC Code:
12352200

Key Documents

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Product Name

ISPA-28, ≥98% (HPLC)

InChI key

YMLINDVVJXDIRW-UHFFFAOYSA-N

InChI

1S/C21H24N6O3/c1-5-26-12-16(13(2)23-26)17-11-18(30-24-17)20(28)22-19-14(3)25(4)27(21(19)29)15-9-7-6-8-10-15/h6-10,12,18H,5,11H2,1-4H3,(H,22,28)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

ISPA-28 is an inhibitor of the plasmodial surface anion channel (PSAC).
ISPA-28 is an inhibitor of the plasmodial surface anion channel (PSAC). ISPA-28 is 800 fold more potent against PSAC expressed by the P. falciparum strain Dd2 over PSAC expressed by the HB23 strain. PSAC is incorporated into the membranes of Plasmodium-infected red blood cells, resulting in increased permeability to nutrients required for pathogen growth.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
093M4711V

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David A Hill et al.
Future microbiology, 5(1), 81-97 (2009-12-22)
Erythrocytes infected with plasmodia, including those that cause human malaria, have increased permeability to a diverse collection of organic and inorganic solutes. While these increases have been known for decades, their mechanistic basis was unclear until electrophysiological studies revealed flux
Paresh Sharma et al.
The Journal of biological chemistry, 288(27), 19429-19440 (2013-05-31)
Acquired antimalarial drug resistance produces treatment failures and has led to periods of global disease resurgence. In Plasmodium falciparum, resistance is known to arise through genome-level changes such as mutations and gene duplications. We now report an epigenetic resistance mechanism

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