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SML0494

Sigma-Aldrich

VU0361737

≥98% (HPLC)

Synonym(s):

CID-44191096, ML128, N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C13H11ClN2O2
CAS Number:
1161205-04-4
Molecular Weight:
262.69
MDL number:
MFCD16618402
UNSPSC Code:
12352200
PubChem Substance ID:
329825444
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

film

color

white

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

COc1cc(NC(=O)c2ccccn2)ccc1Cl

InChI

1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)

InChI key

ARYUXFNGXHNNDM-UHFFFAOYSA-N

Biochem/physiol Actions

VU0361737 is an mGluR4-specific positive allosteric modulator (PAM) with greater than 50 fold selectivity over other mGluR subtypes. The EC50 values for human and rat mGlu4 are 240 and 110 nM, respectively, compared to greater than 10 mM for all other mGluRs.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

Glutamate Receptors (G Protein Family)

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