SML0484
KS-176
≥98% (HPLC)
Synonym(s):
N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide
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About This Item
Empirical Formula (Hill Notation):
C22H19N3O5
CAS Number:
Molecular Weight:
405.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
InChI
1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27)
SMILES string
OCCc1ccc(NC(=O)c2ccccc2NC(=O)c3ccc(cc3)[N+]([O-])=O)cc1
InChI key
LTWQQWSXYYXVGA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 15 mg/mL (clear solution)
storage temp.
2-8°C
Biochem/physiol Actions
KS-176 is a potent specific inhibitor of Breast Cancer Resistance Protein (BCRP) / ATP-binding cassette sub-family G member 2 (ABCG2) with no inhibition of the ATP binding cassette (ABC) transporters P-gp and MRP1.
KS-176 is a potent specific inhibitor of Breast Cancer Resistance Protein (BCRP) / ATP-binding cassette sub-family G member 2 (ABCG2).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ronald E Cannon et al.
Toxicological sciences : an official journal of the Society of Toxicology, 169(2), 475-484 (2019-03-05)
Tetrabromobisphenol A (TBBPA, CAS No. 79-94-7) is a brominated flame retardant used in 90% of epoxy coated circuit boards. Exposures to TBBPA can induce neurotoxicity and disrupt MAPK, estrogen, thyroid, and PPAR-associated signaling pathways. Because these pathways also regulate transporters
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