SML0482
3CAI
≥95% (HPLC)
Synonym(s):
2-Chloro-1-(1H-indol-3-yl)ethanone, 3-Chloroacetyl-indole, Chloromethyl indol-3-yl ketone
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About This Item
Empirical Formula (Hill Notation):
C10H8ClNO
CAS Number:
Molecular Weight:
193.63
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Product Name
3CAI, ≥95% (HPLC)
InChI
1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2
SMILES string
O=C(CCl)C1=CNC2=C1C=CC=C2
InChI key
LLZQFAXTCYDVTR-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
yellow to brown
solubility
DMSO: 5 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Biochem/physiol Actions
3CAI is a potent and specific allosteric inhibitor of Akt1 and Akt2.
3CAI is an orally active, potent and specific allosteric inhibitor of Akt1 and Akt2 that directly binds to Ak1 and Akt2 in an ATP noncompetitive manner.
Features and Benefits
This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
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Ji-Eun Kim et al.
Cell death & disease, 9(5), 546-546 (2018-05-12)
Recently, we have reported that heat shock protein B1 (HSPB1) and purinergic receptor P2X7 (P2RX7) are involved in astroglial autophagy (clasmatodendrosis), following status epilepticus (SE). However, the underlying mechanisms of astroglial autophagy have not been completely established. In the present
[Photometric determination of 3-chloroacetyl indole in the air].
E I Kosterina et al.
Gigiena i sanitariia, (2)(2), 48-49 (1988-02-01)
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