Skip to Content
Merck
CN

SML0468

Dorzolamide

≥98% (HPLC)

Synonym(s):

(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

Empirical Formula (Hill Notation):
C10H16N2O4S3
CAS Number:
120279-96-1
Molecular Weight:
324.44
MDL number:
MFCD00865636
UNSPSC Code:
12352200
PubChem Substance ID:
329824746
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -25 to -35°, c = 1 in methanol

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution, warmed)

storage temp.

room temp

SMILES string

CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI

1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1

InChI key

IAVUPMFITXYVAF-XPUUQOCRSA-N

Gene Information

human ... CA2(760)

Related Categories

Biochem/physiol Actions

Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.
Dorzolamide is a potent carbonic anhydrase II inhibitor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000446009
0000446011
0000446011
0000446009
0000289239

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Daniel Laroche et al.
Journal of glaucoma, 27(10), e158-e161 (2018-07-26)
We describe a novel technique comprising the use of trypan blue to confirm aqueous outflow to collector channels and aqueous veins after goniotomy with the Kahook Dual Blade (New World Medical, Rancho Cucamonga, CA). Intraocular dyes have been safely used
John S Sapienza et al.
Veterinary ophthalmology, 22(4), 520-528 (2018-10-26)
The purpose of this study was to report the preliminary results of a novel micropulse transscleral diode laser cyclophotocoagulation (MP-TSCP) as primary therapy for glaucomatous dogs. Client owned dogs undergoing MP-TSCP therapy at a veterinary referral center. Retrospective study of
Un Chul Park et al.
Retina (Philadelphia, Pa.), 40(7), 1359-1366 (2019-06-06)
To evaluate the efficacy and safety of intravitreal dexamethasone (DEX) implant in retinitis pigmentosa patients with cystoid macular edema (CME). In this randomized, noncontrolled, paired-eye, single crossover clinical trial, one eye of retinitis pigmentosa patients with bilateral CME with central
Yukari Yagi-Yaguchi et al.
Diagnostics (Basel, Switzerland), 10(1) (2020-01-08)
Anti-glaucoma eye drop treatment often induces dry eyes and can lead to poor medication adherence. This study aimed to investigate the effects of 3% diquafosol sodium eye drops on tear function and the ocular surface epithelium in Sod1-/- mice after
Boovizhikannan Thangabalan et al.
Journal of analytical methods in chemistry, 2018, 4596141-4596141 (2018-10-03)
A reversed phase liquid chromatographic method with UV detection at 254 nm for dorzolamide assay in ophthalmic solutions was developed and validated. Chromatographic separation was achieved on a Zorbax SB C18 (250 mm × 4.6 mm, 5 µm) column kept at 30°C with an isocratic mixture
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service