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SML0468

Sigma-Aldrich

Dorzolamide

≥98% (HPLC)

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Synonym(s):
(4S,6S)-4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, 4S,6S-Dorzolamide, L-671,152, MK-507
Empirical Formula (Hill Notation):
C10H16N2O4S3
CAS Number:
120279-96-1
Molecular Weight:
324.44
MDL number:
MFCD00865636
UNSPSC Code:
12352200
PubChem Substance ID:
329824746
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -25 to -35°, c = 1 in methanol

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution, warmed)

storage temp.

room temp

SMILES string

CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI

1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1

InChI key

IAVUPMFITXYVAF-XPUUQOCRSA-N

Gene Information

human ... CA2(760)

Biochem/physiol Actions

Dorzolamide is a potent carbonic anhydrase II inhibitor with an IC50 value of 0.16 nM on human erythrocyte carbonic anhydrase II in vitro. It has been found to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Riku P J Arvola et al.
Cornea, 35(4), 451-455 (2016-02-05)
Treating corneal neurotrophic ulcers is challenging. Topical application of matrix regeneration therapy (RGTA), which is a dextran derivative polymer and heparan sulfate analog, is a promising regenerative therapy and an alternative or additional therapeutic regimen when corneal healing is compromised.
Boovizhikannan Thangabalan et al.
Journal of analytical methods in chemistry, 2018, 4596141-4596141 (2018-10-03)
A reversed phase liquid chromatographic method with UV detection at 254 nm for dorzolamide assay in ophthalmic solutions was developed and validated. Chromatographic separation was achieved on a Zorbax SB C18 (250 mm × 4.6 mm, 5 µm) column kept at 30°C with an isocratic mixture
Yukari Yagi-Yaguchi et al.
Diagnostics (Basel, Switzerland), 10(1) (2020-01-08)
Anti-glaucoma eye drop treatment often induces dry eyes and can lead to poor medication adherence. This study aimed to investigate the effects of 3% diquafosol sodium eye drops on tear function and the ocular surface epithelium in Sod1-/- mice after
Frank Bochmann et al.
Journal of glaucoma, 26(11), 1051-1055 (2017-10-28)
A subluxation or dislocation of the intraocular lens (IOL) is a well-known complication after cataract surgery in patients with pseudoexfoliation syndrome (PEX). Capsular tension rings (CTR) are frequently used to prevent postoperative complications caused by zonular weakness. Here we present
Luciano Quaranta et al.
Journal of glaucoma, 26(11), 987-994 (2017-09-29)
To investigate the efficacy and safety of a treatment strategy with latanoprost and dorzolamide in primary pediatric glaucoma patients partially responsive to surgery. Children with primary pediatric glaucoma having postsurgical untreated intraocular pressure (IOP) between 22 and 26 mm Hg were eligible.
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