Skip to Content
Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

SML0464

Sigma-Aldrich

SPA0355

≥98% (HPLC)

Synonym(s):

N-Methyl-N′-[4-[2-(10H-phenoxazin-10-yl)ethoxy]phenyl]-thiourea

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C22H21N3O2S
CAS Number:
1251839-15-2
Molecular Weight:
391.49
MDL number:
MFCD22666401
UNSPSC Code:
12352200
PubChem Substance ID:
329824742
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white, to tan to gray

solubility

DMSO: 15 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

CNC(=S)Nc1ccc(OCCN2c3ccccc3Oc4ccccc24)cc1

InChI

1S/C22H21N3O2S/c1-23-22(28)24-16-10-12-17(13-11-16)26-15-14-25-18-6-2-4-8-20(18)27-21-9-5-3-7-19(21)25/h2-13H,14-15H2,1H3,(H2,23,24,28)

InChI key

IEFRKIYTMPORCY-UHFFFAOYSA-N

Biochem/physiol Actions

SPA0355 inhibits cytokine and LPS-induced activation of NF-kB in cell-based assays, blocking IKK-2 phosphorylation, degradation, and p65 binding to DNA. In vivo, SPA0355 inhibits paw edema and joint destruction in a mouse collagen induced arthritis model.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
092M4601V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jung-Yeon Kim et al.
Antioxidants (Basel, Switzerland), 9(7) (2020-07-09)
Inflammation and oxidative stress plays an essential role in the pathophysiology of sepsis-associated acute kidney injury (AKI). SPA0355, a thiourea analogue, has been shown to display beneficial effects against a variety of inflammatory diseases arising from its anti-inflammatory and anti-oxidant

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service