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Merck
CN

SML0424

ST247

≥98% (HPLC)

Synonym(s):

3-[[[4-(Hexylamino)-2-methoxyphenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester

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About This Item

Empirical Formula (Hill Notation):
C19H26N2O5S2
CAS Number:
1356497-91-0
Molecular Weight:
426.55
UNSPSC Code:
12352200
PubChem Substance ID:
329825419
NACRES:
NA.77

Key Documents

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Product Name

ST247, ≥98% (HPLC)

SMILES string

CCCCCCNc1ccc(NS(=O)(=O)c2ccsc2C(=O)OC)c(OC)c1

InChI

1S/C19H26N2O5S2/c1-4-5-6-7-11-20-14-8-9-15(16(13-14)25-2)21-28(23,24)17-10-12-27-18(17)19(22)26-3/h8-10,12-13,20-21H,4-7,11H2,1-3H3

InChI key

MRWCGEOYGFZZCJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL (clear solution)

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

ST247 is a PPAR β/δ inverse agonist.
ST247 is a PPAR β/δ selective inverse agonist. The compound is based on the structure of GSK0660, and is 10-fold more potent in blocking the transcription of endogenous target genes: ST247 IC50 = 19 nm vs. GSK0660 IC50 = 210 nM.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000060369
082M4602V

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Jie Yu et al.
The Journal of clinical endocrinology and metabolism, 105(9) (2020-07-01)
Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In the present study we analyzed the effects of peroxisome-proliferator-activated receptor
Christina Blücher et al.
Molecular cancer research : MCR, 18(12), 1849-1862 (2020-08-30)
Recent studies indicate that adipose tissue in obesity promotes breast cancer progression by secreting protumorigenic chemokines, growth factors, and fatty acids. However, the detailed mechanisms by which hypertrophic adipose tissue influences breast cancer cells are still not well understood. Here

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Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

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