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Safety Information

SML0391

Sigma-Aldrich

SB-268262

≥98% (HPLC)

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Synonym(s):
(+/-)-SB-273779, N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Empirical Formula (Hill Notation):
C18H15N3O4S2
CAS Number:
217438-17-0
Molecular Weight:
401.46
MDL number:
MFCD10565932
UNSPSC Code:
41106305
PubChem Substance ID:
329825388
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

CN(C(=O)c1ccc(c(c1)[N+]([O-])=O)S(=O)c2nccs2)c3ccccc3C

InChI

1S/C18H15N3O4S2/c1-12-5-3-4-6-14(12)20(2)17(22)13-7-8-16(15(11-13)21(23)24)27(25)18-19-9-10-26-18/h3-11H,1-2H3

InChI key

YXHLPJQQPOMPGE-UHFFFAOYSA-N

Biochem/physiol Actions

SB-268262 is a selective non-peptide antagonist at the CGRP1 receptor. SB-268262 inhibits CGRP binding, and CGRP-mediated stimulation of adenylyl cyclase activity in human neuroblastoma cells with IC50 values of 240 and 830 nM, respectively.

Features and Benefits

This compound is featured on the Calcitonin Gene-Related Peptides page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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