SML0377
(S)-FTY720 phosphate
≥94% (HPLC)
Synonym(s):
(+)-(S)-FTY 720 phosphate, (2S)-2-Amino-2-[2-(4-octylphenyl)ethyl]-1-(dihydrogen phosphate)-1,3-propanediol), (S)-FTY 720P
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About This Item
Empirical Formula (Hill Notation):
C19H34NO5P
CAS Number:
Molecular Weight:
387.45
UNSPSC Code:
12352211
Product Name
(S)-FTY720 phosphate, ≥94% (HPLC)
assay
≥94% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 0.3 mg/mL, clear (warmed)
storage temp.
−20°C
Biochem/physiol Actions
FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1P) receptor agonist and immunomodulatory agent, the active metabolite of FTY720.
FTY20 phosphate (FTY720-P) is a sphingosine 1-phosphate (S1PR) receptor agonist and immunomodulatory agent, the active metabolite of FTY720. FTY720P acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5), with IC50 values of 0.2-6 nM.
Features and Benefits
This compound is featured on the Lysophospholipid Receptors and Lysophospholipid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Nitai C Hait et al.
Nature neuroscience, 17(7), 971-980 (2014-05-27)
FTY720 (fingolimod), an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. We show that FTY720 enters the nucleus, where it is
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