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Merck
CN

SML0338

Lornoxicam

≥98% (HPLC)

Synonym(s):

6-Chloro-4-hydroxy-2-methyl-N-2-pyridinyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide, Chlortenoxicam, Ro 13-9297, TS 110

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About This Item

Empirical Formula (Hill Notation):
C13H10ClN3O4S2
CAS Number:
70374-39-9
Molecular Weight:
371.82
NACRES:
NA.77
PubChem Substance ID:
329825343
UNSPSC Code:
12352200
MDL number:
MFCD00866163

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InChI

1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)

SMILES string

CN1C(C(=O)Nc2ccccn2)=C(O)c3sc(Cl)cc3S1(=O)=O

InChI key

WLHQHAUOOXYABV-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: >5 mg/mL (warmed)

storage temp.

−20°C

Quality Level

100

Related Categories

General description

Lornoxicam belongs to the oxicam class. It has anti-inflammatory and antipyretic properties. Lornoxicam prevents the synthesis of prostaglandin (PG) by inhibiting cyclo-oxygenase. It is used to relieve various types of symptoms associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.

Application

Lornoxicam has been used as a drug in melanin binding study with cassette dosing and rapid equilibrium dialysis inserts.

Biochem/physiol Actions

Lornoxicam is an oxicam-class NSAID with strong analgesic properties.
Lornoxicam is an oxicam-class NSAID; cyclooxygenase inhibitor.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000162519
0000162520
0000160698
0000162520

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Honglei Xi et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(2), 325-330 (2012-05-15)
Ion pair is an effective chemical approach to enhance skin penetration of drugs. The aim of this work was to investigate the skin enhancement mechanism of ion pairs for lornoxicam (LOX) with organic amines from the standpoint of ion-pair stability.
Anesteziologiia i reanimatologiia, (6)(6), 38-41 (2012-03-03)
The patient-controlled analgesia with two devices allows to compare analgesic agent and to regulate quantity and quality of multimodal analgesia compounds. The aim of the study is to compare efficiency of analgesic agents in method of patient controlled analgesia with
Fatih Ozkan et al.
Journal of endourology, 26(6), 691-696 (2011-11-05)
Shockwave lithotripsy (SWL) is one of the most important treatment modalities for urinary stone disease. The procedure may cause pain, and patient relaxation and cooperation are crucial in maintaining stone localization for optimal fragmentation and patient comfort during the procedure.
Fang Zhao et al.
Journal of fluorescence, 22(1), 529-535 (2011-10-05)
Based on the micelle synergism mechanism, a simple and sensitive flow injection chemiluminescence (FI-CL) method for the assay of lornoxicam was described. The CL signal generated from the reaction of Ce (IV) with lornoxicam in acidic solution was very weak
M A Agapov et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (7)(7), 18-23 (2012-03-01)
Acute pancreatitis is a disease of variable severity. In which some patients experience mild, self-limited attacks while others manifest a severe, highly morbid, and frequently lethal attack. The exact mechanisms by which diverse etiological factors induce an attack are still
View All Related Papers

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