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Merck
CN

SML0261

SC66

≥98% (HPLC)

Synonym(s):

(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone

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About This Item

Empirical Formula (Hill Notation):
C18H16N2O
CAS Number:
871361-88-5
Molecular Weight:
276.33
UNSPSC Code:
12352200
PubChem Substance ID:
329825269
MDL number:
MFCD05025493

Key Documents

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Product Name

SC66, ≥98% (HPLC)

InChI

1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+

SMILES string

O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3

InChI key

CYVVJSKZRBZHAV-UNZYHPAISA-N

assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: ≥5 mg/mL (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

SC66 is a dual function Akt inhibitor.
SC66 is an allosteric inhibitor of Akt that prevents binding of PIP3 to the PH domain. The compound prevents activation of Akt by PIP3, and also facilitates ubiquination and degradation of Akt. SC66 inhibition is maintained against a cancer relevant Akt mutation (E17K) that is resistant to the actions of PIP3K inhibitors. SC66 is active in vivo, and significantly inhibits the ability of HEK293T cells to form colonies in soft agar and tumor growth in nude mice.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
022M4608V

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Chao-Yu Loung et al.
Molecules (Basel, Switzerland), 24(18) (2019-09-22)
Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells was determined and compared with the effect of
Yanan Kong et al.
Journal of cellular physiology, 234(11), 20801-20815 (2019-04-30)
In diabetes, the number of bone mesenchymal stem cells (MSCs) decreases and their differentiation is impaired. However, the exact mechanism is unclear. Patients with diabetes often experience sympathetic nerve injury. Norepinephrine (NE), a major mediator of the sympathetic nervous system
Q Lu et al.
Cell death & disease, 6, e2005-e2005 (2015-12-04)
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In
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Cellular signalling, 27(7), 1478-1487 (2015-03-24)
Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cytosolic functions. Many proteins containing one of the two known PCNA-interacting motifs, the
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