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Key Documents

Safety Information

SML0126

Sigma-Aldrich

OBA-09 hydrate

≥98% (HPLC)

Synonym(s):

2-(1,2-Dioxopropoxy)benzoic acid hydrate, O-Pyruvoylsalicylic acid hydrate

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About This Item

Empirical Formula (Hill Notation):
C10H8O5 · xH2O
CAS Number:
Molecular Weight:
208.17 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥24 mg/mL

storage temp.

2-8°C

SMILES string

O.CC(=O)C(=O)Oc1ccccc1C(O)=O

InChI

1S/C10H8O5.H2O/c1-6(11)10(14)15-8-5-3-2-4-7(8)9(12)13;/h2-5H,1H3,(H,12,13);1H2

InChI key

DLKFQAHWYMEWIK-UHFFFAOYSA-N

Application

OBA-09 hydrate may be used in cell signaling studies.

Biochem/physiol Actions

Neuroprotective agent
OBA-09 is a neuroprotective agent. It is an ester of pyruvate and salicylic acid that acts as a multi-functional agent to protect against ischemic damages to the brain. Administration of 5 mpk OBA-09 following middle cerebral artery occlusion (MCAO) or oxygen-glucose deprivation (OGD) models of ischemic injury in rats prevents lipid peroxidation, ROS production and causes the recovery of NAD and ATP concentrations to near basal levels. The compound leads to reduction of infarct volume and also accelerates the recovery of behavioral and neurological deficits.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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