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Merck
CN

SML0123

Deflazacort

≥98% (HPLC)

Synonym(s):

(11β,16β)-21-(acetyloxy)-11-hydroxy-2′-methyl-5′H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione, 11β,21-dihydroxy-2′-methyl-5′βH-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione 2′-acetate, DL-458-IT, L-5458, azacort, oxazacort, pregna-1,4-diene-11β,21-diol-3,20-dione[17α,16α-d]-2′-methyloxazoline 21-acetate

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About This Item

Empirical Formula (Hill Notation):
C25H31NO6
CAS Number:
14484-47-0
Molecular Weight:
441.52
NACRES:
NA.77
PubChem Substance ID:
329825173
UNSPSC Code:
51111800
EC Number:
238-483-7
MDL number:
MFCD00866106

Key Documents

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InChI key

FBHSPRKOSMHSIF-GRMWVWQJSA-N

InChI

1S/C25H31NO6/c1-13-26-25(20(30)12-31-14(2)27)21(32-13)10-18-17-6-5-15-9-16(28)7-8-23(15,3)22(17)19(29)11-24(18,25)4/h7-9,17-19,21-22,29H,5-6,10-12H2,1-4H3/t17-,18-,19-,21+,22+,23-,24-,25+/m0/s1

SMILES string

CC(=O)OCC(=O)[C@@]12N=C(C)O[C@@H]1C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]23C

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... NR3C1(2908)

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Biochem/physiol Actions

Deflazacort is an Anti-inflammatory glucocorticoid
Deflazacort is an anti-inflammatory and immunosuppressant glucocorticoid.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000479246
0000375408
0000366529
0000375408
0000366529

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Pulukool Sandhya et al.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 18(1), 33-35 (2011-12-14)
We describe here a case of longstanding rheumatoid arthritis (RA) presenting with recurrent episodes of epigastric pain, melena, nonprogressive dysphagia, and hoarseness associated with persistent peripheral blood eosinophilia. Her RA was clinically inactive, but she had significant lymphadenopathy and hepatosplenomegaly.
Sergio E Hernandez-Da Mota et al.
Ocular immunology and inflammation, 19(5), 367-369 (2011-10-06)
To describe a systemic lupus erythematosus (SLE) relapse, which presented as frosted branch retinal angiitis. Clinical case report. A 16-year-old female patient had an SLE relapse that appeared as frosted branch angiitis while being treated with deflazacort and azathioprine. Complete
Miguel A López-González et al.
Acta otorrinolaringologica espanola, 63(3), 165-172 (2011-12-14)
Idiopathic sudden sensorineural hearing loss is a hearing disorder of unknown cause. The spontaneous recovery rate ranges from 50 to 75% of the patients. Scientific experiments on animals support the present study in patients with sudden deafness treated with sounds.
Corrado Angelini et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 31(1), 9-15 (2012-06-05)
Steroids have been used since two decades and several trials were conducted to establish their efficacy in DMD patients with various regimens. The clinical outcomes showed increased function in the treated boys, and in a single trial with deflazacort, prolongation
Elena Stacy Mazzone et al.
PloS one, 8(1), e52512-e52512 (2013-01-18)
The aim of the study was i) to assess the spectrum of changes over 24 months in ambulant boys affected by Duchenne muscular dystrophy, ii) to establish the difference between the first and the second year results and iii) to
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