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ZINC Compound 792949; 4-Chloro-3-[[(3-nitrophenyl)amino]sulfonyl]-benzoic acid
C13H9ClN2O6S
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Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥23 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)c1ccc(Cl)c(c1)S(=O)(=O)Nc2cccc(c2)[N+]([O-])=O
InChI
1S/C13H9ClN2O6S/c14-11-5-4-8(13(17)18)6-12(11)23(21,22)15-9-2-1-3-10(7-9)16(19)20/h1-7,15H,(H,17,18)
InChI key
IIJQJWNGBILZCU-UHFFFAOYSA-N
Application
CTP inhibitor may be used in cell signaling studies.
CTP inhibitor has been used in mouse to study the transition of endothelial to mesenchymal cells.
CTP inhibitor has been used in mouse to study the transition of endothelial to mesenchymal cells.
Biochem/physiol Actions
CTP inhibitor blocks the exchange of tricarboxylates the key intermediates in anabolism and catabolism by mitochondrial citrate transport protein (CTP).
CTP Inhibitor is an inhibitor of mitochondrial citrate transport protein, was the first purely competitive inhibitor to be discovered and is more potent than BTC.
WGK
WGK 3
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Molecular and cellular pharmacology, 2(3), 101-110 (2010-08-06)
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Cell metabolism, 32(6), 967-980 (2020-12-03)
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To study when and where active genes replicated in early S phase are transcribed, a series of pulse-chase experiments are performed to label replicating chromatin domains (RS) in early S phase and subsequently transcription sites (TS) after chase periods of
A metabolic basis for endothelial-to-mesenchymal transition
Molecular Cell, 69, 689-698 (2018)
Anti-cancer agents in medicinal chemistry, 15(3), 374-381 (2014-12-17)
Lipogenesis is considered to be a very important aspect of cancer metabolism and targeting de novo lipid synthesis or related pathways are among novel approaches to treat cancer. Many targets of the pathway including ATP-citrate lyase (ACLY), acetyl-CoA carboxylase and
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