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SML0045

Sigma-Aldrich

Salvianolic acid A hydrate

≥98% (HPLC)

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Synonym(s):
Dan phenolic acid A hydrate
Empirical Formula (Hill Notation):
C26H22O10 · xH2O
CAS Number:
96574-01-5
Molecular Weight:
494.45 (anhydrous basis)
MDL number:
MFCD20527310
UNSPSC Code:
12352200
PubChem Substance ID:
329825115
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

yellow

solubility

H2O: ≥19 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

O.OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c2ccc(O)c(O)c2\C=C\c3ccc(O)c(O)c3

InChI

1S/C26H22O10.H2O/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15;/h1-12,23,27-31,33H,13H2,(H,34,35);1H2/b6-1+,10-5+;/t23-;/m1./s1

InChI key

XFUSRNNWIRPEDG-FYLUTCCGSA-N

Application

Salvianolic acid A hydrate may be used in cell signaling studies.
Salvianolic acid A hydrate has been used as rosmarinic acid derivative for the inhibition of DNA polymerase e in human cell lines.

Biochem/physiol Actions

Salvianolic acid A acts as scavengers of reactive oxygen species, reduces the adherence of leukocytes to endothelial cells, inhibits matrix metalloproteinases and inflammation. It has cardioprotective effects as it suppresses apoptosis, reduces lipid peroxidation in damaged cardiac tissue and decreases the leakage of lactic acid dehydrogenase.
Salvianolic acid A is cell protective antioxidant originally isolated from Salvia. It has been found to attenuate PDGF-induced ROS formation in hepatic stellate cells and protected against isoproterenol-induced myocardial damage in rats.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Huaying Fan et al.
Evidence-based complementary and alternative medicine : eCAM, 2012, 508938-508938 (2011-07-27)
Salvianolic acid A (SAA), one of the major active components of Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity. This study aims to investigate the cardioprotection of SAA
Xiao-Juan Lai et al.
Fitoterapia, 82(6), 883-888 (2011-05-18)
Salviae miltiorrhizae is one of the most commonly used herbal plants in the treatment of numerous ailments including cardiovascular diseases for hundreds of years. According to the theory of traditional Chinese herbal medicine, S. miltiorrhizae is always used in combination
Baohong Jiang et al.
PloS one, 8(3), e59621-e59621 (2013-03-28)
Cardiac fibrosis is a deleterious consequence of hypertension which may further advance to heart failure and increased matrix metalloproteinase-9 (MMP-9) contributes to the underlying mechanism. Therefore, new therapeutic strategies to attenuate the effects of MMP-9 are urgently needed. In the
Jing Wang et al.
Folia neuropathologica, 59(1), 50-66 (2021-05-11)
More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime. And in 2017, more than 1.39 billion
Heng-ai Zhang et al.
Biochemical and biophysical research communications, 421(3), 479-483 (2012-04-21)
Salvianolic acid A (Sal A) is a polyphenol extracted from the root of the Salvia miltiorrhiza bunge. Hydrogen peroxide (H(2)O(2)) is a major reactive oxygen species (ROS), which has been implicated in stroke and other neurodegenerative diseases, including Alzheimer's disease
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