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SML0038

Sigma-Aldrich

Fluvastatin sodium hydrate

≥98% (HPLC)

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Synonym(s):
(±)-(3R*,5S*,6E)-7-[3-(4-Fluorophenyl)-1-(1-methyethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate
Empirical Formula (Hill Notation):
C24H25FNO4 · Na · xH2O
CAS Number:
93957-55-2
Molecular Weight:
433.45 (anhydrous basis)
MDL number:
MFCD20488050
UNSPSC Code:
12352204
PubChem Substance ID:
329825108
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

H2O: ≥9 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13

InChI

1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1

InChI key

KKEMYLLTGGQWCE-PMRANXHDSA-M

Application

Fluvastatin sodium hydrate has been used:
  • to examine its effect on β -glucan-induced training on immunity
  • to investigate the effect of statins on the number of uncoupling protein 1 (UCP1)+ cells
  • to determine its effect on insulin degrading enzyme (IDE) secretion from astrocytes
  • to treat and study its effect on human umbilical vein endothelial cells (HUVECs) in vitro

Fluvastatin sodium hydrate has been used:
  • to test its anti-hepatitis C virus (HCV) activity
  • as a cholesterol inhibitor
  • to study its effects on β-glucan-induced monocyte immune training

Biochem/physiol Actions

Fluvastatin has antifungal activity.
Fluvastatin is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Avasimibe: a novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles
Hu L, et al.
Antiviral Research, 148, 5-14 (2017)
Kazuho Sakamoto et al.
The Journal of pharmacology and experimental therapeutics, 338(1), 62-69 (2011-04-07)
HMG-CoA reductase inhibitor statins are used for the treatment of hypercholesterolemia. However, statins have adverse effects on skeletal muscles with unknown mechanism. We have reported previously that fluvastatin induced vacuolation and cell death in rat skeletal myofibers by depleting geranylgeranylpyrophosphate
Weibel-Palade body size modulates the adhesive activity of its von Willebrand Factor cargo in cultured endothelial cells
Ferraro F, et al.
Scientific reports, 6, 32473-32473 (2016)
Metabolic induction of trained immunity through the mevalonate pathway
Bekkering S, et al.
Cell, 172(1-2), 135-146 (2018)
Current Cardiovascular Drugs (2005)
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