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SMB01073

Sigma-Aldrich

Eurycomanone

≥90% (LC/MS-ELSD)

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Synonym(s):
Pasakbumin A
Empirical Formula (Hill Notation):
C20H24O9
CAS Number:
84633-29-4
Molecular Weight:
408.40
MDL number:
MFCD31726288
UNSPSC Code:
12352205
NACRES:
NA.25

biological source

plant

Assay

≥90% (LC/MS-ELSD)

form

solid

mol wt

408.4

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

InChI

1S/C20H24O9/c1-7-4-10(21)13(23)17(3)9(7)5-11-18-6-28-20(27,16(17)18)12(22)8(2)19(18,26)14(24)15(25)29-11/h4,9,11-14,16,22-24,26-27H,2,5-6H2,1,3H3/t9-,11+,12+,13+,14-,16+,17+,18+,19-,20-/m0/s1

InChI key

UCUWZJWAQQRCOR-OKNZMGBLSA-N

General description

Eurycomanone, also known as Pasakbumin A, is a bioactive quassinoid natural compound commonly derived from Eurycoma longifolia (Tongkat Ali). Current research indicates that this plant metabolite is an inhibitor and may possess diverse biological activities, including antitumor, antimalarial, and anticancer properties.

Application

Eurycomanone is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem/physiol Actions

Eurycomanone inhibited Jurkat and K562 leukemia cells viability and proliferation without affecting healthy cells and enhanced testosterone steroidogenesis.

Features and Benefits

  • Suitable for Biochemical and Biomedical research
  • Versatile and adaptable for wide variety of laboratory and research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Shéhérazade Hajjouli et al.
Molecules (Basel, Switzerland), 19(9), 14649-14666 (2014-09-18)
Eurycomanone and eurycomanol are two quassinoids from the roots of Eurycoma longifolia Jack. The aim of this study was to assess the bioactivity of these compounds in Jurkat and K562 human leukemia cell models compared to peripheral blood mononuclear cells
Bin-Seng Low et al.
Journal of ethnopharmacology, 149(1), 201-207 (2013-07-03)
Eurycoma longifolia Jack (Simaroubaceae family), known locally as 'Tongkat Ali' by the ethnic population, is popularly taken as a traditional remedy to improve the male libido, sexual prowess and fertility. Presently, many tea, coffee and carbonated beverages, pre-mixed with the

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