All Photos(1)
Synonym(s):
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-isobutyl-trideca-2,4,12-trienamide, Pipyahyine
Empirical Formula (Hill Notation):
C24H33NO3
Recommended Products
Assay
≥90% (LC/MS-ELSD)
form
solid
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
InChI
1S/C24H33NO3/c1-20(2)18-25-24(26)14-12-10-8-6-4-3-5-7-9-11-13-21-15-16-22-23(17-21)28-19-27-22/h8,10-17,20H,3-7,9,18-19H2,1-2H3,(H,25,26)/b10-8+,13-11+,14-12+
InChI key
FPMPOFBEYSSYDQ-AUVZEZIHSA-N
Related Categories
General description
Guineensine, also known as Pipyahyine, is an alkaloid and a member of benzodioxoles is a natural product commonly available from Piper Sp.(P. nigrum and P. longum and P. retrofractum) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including antimicrobial, anticancer, anti-inflammatory, antiviral and antioxidant properties.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
According to the existing research, Guineensine inhibits endocannabinoid uptake, leading to significant anti-inflammatory and analgesic effects, and also interacts with various receptors, including dopamine transporter DAT, 5HT2A, and sigma receptors, suggesting potential polypharmacological activity.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
For additional information on our range of Biochemicals, please complete this form.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Ruben Bartholomäus et al.
ChemMedChem, 14(17), 1590-1596 (2019-07-20)
Guineensine ((2E,4E,12E)-13-(benzo[d][1,3]dioxol-5-yl)-N-isobutyltrideca-2,4,12-trienamide) is a plant-derived natural product that inhibits reuptake of the endocannabinoid anandamide with sub-micromolar potency. We have established a highly efficient total synthesis of guineensine, which provided the natural product in only five steps from commercially available 3-nonyn-1-ol
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