SMB00607
Amoxicillin trihydrate: potassium clavulanate (4:1)
Synonym(s):
Amoxicillin Trihydrate: Potassium Clavulanate
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About This Item
NACRES:
NA.85
UNSPSC Code:
51285005
form
powder
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.)
color
white to yellow
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
Related Categories
Application
Amoxicillin trihydrate: potassium clavulanate (4:1) has been used to study its effect on the viral déjà vu disease (neonatal intracerebral (i.c.) infection) in mice model.
Biochem/physiol Actions
Amoxicillin trihydrate is a broad-spectrum, β-lactam antibiotic. It inhibits the cross-linkage between linear peptidoglycan polymer chains that are the major component of both Gram-positive and Gram-negative bacteria. Since amoxicillin is degraded by β-lactamases, it does not show activity against bacteria which produce these enzymes.
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.
Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.
Clavulanate is a β-lactam antibiotic related to the penicillins. Clavulanate competitively and irreversibly inhibits a wide variety of β-lactamases found in bacteria that are resistant to penicillins and cephalosporins.
Formulations of amoxicillin with clavulanic acid prevent the degradation of amoxicillin by β-lactamase enzymes. This increases amoxicillin′s antibacterial activity against bacteria normally resistant to β-lactam antibiotics.
General description
Amoxicillin trihydrate is a semisynthetic antibiotic, that is used as a medicine.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Never allow product to get in contact with water during storage.
Material is a powdered mixture of 4 parts amoxicillin trihydrate to 1 part potassium clavulanate.
Packaging
1G
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Never allow produc to get in contact with water during storage.
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Danger
hcodes
Hazard Classifications
Flam. Sol. 2 - Resp. Sens. 1 - Self-heat. 2 - Skin Sens. 1
supp_hazards
Storage Class
4.2 - Pyrophoric and self-heating hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Preparation and characterization of Sn/Zn/TiO2 photocatalyst for enhanced amoxicillin trihydrate degradation
Mohammadi R, et al.
Desalination and Water Treatment, 53(7), 1995-2004 (2015)
R N Brogden et al.
Drugs, 18(3), 169-184 (1979-09-01)
Amoxycillin, an acid stable semisynthetic penicillin shown to be effective against a wide range of infections when given orally, is now available for intramuscular and intravenous injection. Amoxycillin has an antibacterial spectrum and level of activity essentially the same as
In vitro antimicrobial activity of 6(D(-) -amino-p-hydroxyphenylacetamido) penicillanic acid, a new semisynthetic penicillin.
H C Neu et al.
Antimicrobial agents and chemotherapy, 10, 407-410 (1970-01-01)
A P Ball et al.
Lancet (London, England), 1(8169), 620-623 (1980-03-22)
Clavulanic acid is an inhibitor of certain beta-lactamases, notably those enzymes which inactivate the penicillins and cause resistance of important bacteria to these antibiotics. Microbiological, pharmacological, and clinical studies show that clavulanic acid in combination with amoxycillin is effective and
Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping
Di Liberto G, et al.
Cell (2018)
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