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Merck
CN

SMB00472

Palmatine chloride

≥98% (HPLC)

Synonym(s):

Berbinium, Dibenzo[a,g]quinolizinium,5,6-dihydro-2,3,9,10-tetramethoxychloride, Fibrauretin chloride

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About This Item

Empirical Formula (Hill Notation):
C21H22ClNO4
CAS Number:
10605-02-4
Molecular Weight:
387.86
NACRES:
NA.25
PubChem Substance ID:
329825027
UNSPSC Code:
12352205
MDL number:
MFCD00016656

Key Documents

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Product Name

Palmatine chloride, ≥98% (HPLC)

InChI

1S/C21H22NO4.ClH/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4;/h5-6,9-12H,7-8H2,1-4H3;1H/q+1;/p-1

SMILES string

COC1=CC2=C(C=C1OC)CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C32.[Cl-]

InChI key

RLQYRXCUPVKSAW-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

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Application

Palmatine chloride has been used to test its effects as an inhibitor of soluble epoxide hydrolase (sEH) in vitro.

Biochem/physiol Actions

Palmatine chloride acts as a microbial collagenase inhibitor and a potential anti-infective agent. It possesses many other pharmacological properties such as antioxidant, anti-inflammatory, anticancer, anti-viral, and neuroprotective.

General description

Palmatineis an isoquinoline alkaloid. Palmatine chloride (PMTCl) is a protoberberine isoquinoline alkaloid with no ketone group and a soluble drug form of palmatine. It has low hygroscopic stability because of chloride ions present in its structure. PMTCl is a natural compound found in the rhizomes of Coptischinensis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000409429
0000409429
0000404827
0000404827
0000248263

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Jang Hoon Kim et al.
Current issues in molecular biology, 44(9), 4282-4289 (2022-09-23)
The quaternary isoquinoline alkaloids of palmatine (1), berberine (2), and jatrorrhizine (3) were evaluated in terms of their ability to inhibit soluble epoxide hydrolase (sEH). They had similar inhibitory activities, with IC50 values of 29.6 ± 0.5, 33.4 ± 0.8
Improving hygroscopic stability of palmatine chloride by forming a pharmaceutical salt cocrystal of palmatine chloride-gallic acid with neutral molecule
Zhang YN, et al.,
Journal of drug delivery science and technology, 66, 102839-102839 (2021)
Georgiana Nitulescu et al.
Life (Basel, Switzerland), 12(12) (2022-12-24)
Bacterial virulence factors are mediating bacterial pathogenesis and infectivity. Collagenases are virulence factors secreted by several bacterial stains, such as Clostridium, Bacillus, Vibrio and Pseudomonas. These enzymes are among the most efficient degraders of collagen, playing a crucial role in

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