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SMB00113

Sigma-Aldrich

6-Geranyl-7-hydroxycoumarin

≥95% (LC/MS-ELSD)

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Synonym(s):
6-(3,7-Dimethyl-2,6-octadienyl)-7-hydroxycoumarin, Ostruthin, Ostruthine
Empirical Formula (Hill Notation):
C19H22O3
CAS Number:
148-83-4
Molecular Weight:
298.38
MDL number:
MFCD07771988
UNSPSC Code:
12352205
PubChem Substance ID:
329824791
NACRES:
NA.25

Assay

≥95% (LC/MS-ELSD)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

C\C(C)=C\CC\C(C)=C\Cc1cc2C=CC(=O)Oc2cc1O

InChI

1S/C19H22O3/c1-13(2)5-4-6-14(3)7-8-15-11-16-9-10-19(21)22-18(16)12-17(15)20/h5,7,9-12,20H,4,6,8H2,1-3H3/b14-7+

InChI key

INBMTJJPUABOQJ-VGOFMYFVSA-N

Related Categories

General description

Natural product derived from plant source.

Pictograms

Environment
GHS09

Signal Word

Warning

Hazard Statements

H410

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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J Qi et al.
Bioscience, biotechnology, and biochemistry, 63(8), 1501-1502 (1999-09-29)
A search for neuritogenic compounds in Chinese herbs resulted in the isolation of two known substances, ostruthin and (-)-bornyl ferulate, from Notopterygium incisum (and/or N. forbesii). Both compounds induced comparable neurite-like structures in 20% of rat PC12 cells at 2
Andreas Schinkovitz et al.
Planta medica, 69(4), 369-371 (2003-04-24)
Following a bioassay-guided fractionation, ostruthin (6-geranyl-7-hydroxycoumarin) was isolated from the roots of Peucedanum ostruthium Koch (Apiaceae) as a compound with pronounced in vitro activity against several species of rapidly growing Mycobacteria, namely Mycobacterium abscesus, M. aurum, M. fortuitum, M. phlei
Y Cai et al.
Carcinogenesis, 18(8), 1521-1527 (1997-08-01)
Several naturally occurring coumarins previously found to be potent inhibitors of mouse hepatic ethoxyresorufin-O-deethylase (EROD) and/or pentoxyresorufin-O-dealkylase (PROD) were examined for their effects on formation of benzo[a]pyrene (B[a]P) and 7,12-dimethylbenz[a]anthracene (DMBA) DNA adducts in mouse epidermis, as well as, their
Feng Li et al.
Planta medica, 78(8), 796-799 (2012-04-21)
During a search for potent anticancer agents from natural products based on an anti-austerity strategy, we found that a CHCl3 extract of Rhizoma et Radix Notopterygii (Qianghuo), a Chinese crude drug, exhibited strong cytotoxicity against PANC-1 human pancreatic cancer cells
Helge Joa et al.
Journal of natural products, 74(6), 1513-1516 (2011-06-02)
Inhibition of vascular smooth muscle cell (VSMC) proliferation is of substantial interest in combating cardiovascular disease. A dichloromethane extract from the rhizomes of Peucedanum ostruthium, a traditionally used Austrian medicinal plant with anti-inflammatory properties, was examined for a putative antiproliferative

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