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Merck
CN

SMB00081

Wogonoside

≥95% (LC/MS-ELSD)

Synonym(s):

5,7-Dihydroxy 8-methoxyflavone 7-glucuronide, Glychionide B, Oroxindin, Wogonin 7-glucuronide

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About This Item

Empirical Formula (Hill Notation):
C22H20O11
CAS Number:
51059-44-0
Molecular Weight:
460.39
NACRES:
NA.25
PubChem Substance ID:
329824759
UNSPSC Code:
12352205
MDL number:
MFCD08704808

Key Documents

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assay

≥95% (LC/MS-ELSD)

form

solid

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

InChI

1S/C22H20O11/c1-30-18-13(32-22-17(27)15(25)16(26)20(33-22)21(28)29)8-11(24)14-10(23)7-12(31-19(14)18)9-5-3-2-4-6-9/h2-8,15-17,20,22,24-27H,1H3,(H,28,29)/t15-,16-,17+,20-,22+/m0/s1

SMILES string

COc1c(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc(O)c3C(=O)C=C(Oc13)c4ccccc4

InChI key

LNOHXHDWGCMVCO-NTKSAMNMSA-N

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General description

Natural product derived from plant source.

Biochem/physiol Actions

Wogonoside, a flavanoid, is known for its anti-inflammatory properties. Wogonoside may have therapeutic potential for use in diseases which involve the development of inflammation and angiogenesis through its inhibition of LPS-induced angiogenesis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
122228183V
122228-183V

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Yan Yan et al.
Chinese medicine, 13, 54-54 (2018-11-06)
Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been reported, such as enhanced anti-ovarian cancer, antioxidative activity, and neuroprotective
Yan Chen et al.
Toxicology, 259(1-2), 10-17 (2009-05-12)
Wogonoside, one flavonoid derived from the root of Scutellaria baicalensis Georgi, has been reported for its anti-inflammation activity; however, whether it can inhibit inflammation-induced angiogenesis is still unclear. In the present study, we evaluated the effect of wogonoside on lipopolysaccharide
R Xiao et al.
Human & experimental toxicology, 36(11), 1169-1176 (2016-12-13)
Wogonoside is the main flavonoid of the traditional Chinese medicinal herb Scutellaria baicalensis Georgi and has been found to induce growth suppression in myelogenous leukemia cells. However, its activity in T acute lymphoblastic leukemia (T-ALL) is still unclear. In this
Xiao-Yan Wei et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1061-1062, 248-255 (2017-08-02)
A rapid, sensitive, and selective UPLC-TQ-MS/MS method was established and validated for the determination and pharmacokinetic investigation of rhein, coptisine, berberine, palmatine, baicalin and wogonoside from Sanhuang Xiexin Decoction (SXD) extracts. A Waters BEH C
Zhenyu Zhu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 878(24), 2184-2190 (2010-07-21)
The aim of this study was to compare the pharmacokinetics of baicalin and wogonoside in rats following oral administration of Xiaochaihu Tang (Minor Radix Bupleuri Decoction) and Radix scutellariae extract. Thus, a specific LC-MS method was developed and validated for
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