All Photos(1)
Empirical Formula (Hill Notation):
C88H124N24O22
Molecular Weight:
1870.07
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
product name
KISS 107-121,
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Application
Kisspeptins are a family of peptides encoded by the KISS-1 gene that are involved in GPR54 mediated cell signaling. Kiss-1 gene products are involved in metastasis suppression and the regulation of gonadotropin-releasing hormone (GnRH) secretion. A variety of kisspeptin peptides are available for use to study their unique functions.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge.
Clarkson J, d'Anglemont de Tassigny X, et al.
The Journal of Neuroscience, 28, 8671-8677 (2008)
E Papaoiconomou et al.
In vivo (Athens, Greece), 25(3), 343-354 (2011-05-18)
The Kiss-1 gene encodes a secreted protein that is proteolytically cleaved to produce a number of structurally related peptides, with high interspecies conservation, globally termed kisspeptins. The original niche for the role of kisspeptin in human physiology is derived from
Rafael Pineda et al.
Progress in brain research, 181, 55-77 (2010-05-19)
Reproductive maturation and function are maintained by a complex neurohormonal network that integrates at the so-called hypothalamic-pituitary-gonadal (HPG) axis. This system is hierarchically controlled by the decapeptide, GnRH, which in turn is under the dynamic regulation of multiple stimulatory and
Naresh Kumar Hanchate et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(3), 932-945 (2012-01-21)
Reproduction is controlled in the brain by a neural network that drives the secretion of gonadotropin-releasing hormone (GnRH). Various permissive homeostatic signals must be integrated to achieve ovulation in mammals. However, the neural events controlling the timely activation of GnRH
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