SCP0168
Histone Deacetylase Substrate
≥95% (HPLC), lyophilized
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About This Item
Empirical Formula (Hill Notation):
C23H31N3O6
Molecular Weight:
445.51
UNSPSC Code:
12352204
NACRES:
NA.32
Product Name
Histone Deacetylase Substrate,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥85%
storage condition
protect from light
storage temp.
−20°C
Application
BOC-Ac-Lys-AMC (MAL) is used as a fluorogenic substrate for assaying both human zinc and NAD+-dependent histone deacetylases.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Birgit Heltweg et al.
Analytical biochemistry, 319(1), 42-48 (2003-07-05)
Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have previously reported Boc(Ac)Lys-AMC, also termed MAL, as a fluorescent substrate for HDACs. Now we present a modification
Neetinkumar D Reddy et al.
Chemico-biological interactions, 233, 81-94 (2015-04-01)
The potential of cinnamic acid as an anti-inflammatory and anti-cancer agent has been studied previously. In our investigation, novel bio-isosters of cinnamyl sulfonamide hydroxamate were synthesized, characterized and confirmed for their structure and evaluated for cytotoxicity. Three NCEs namely, NMJ-1
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