SCP0155
GLP-2 1-33 rat / Preproglucagon 126-158 / Glp 2 rat
≥95% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C166H256N44O56S1
Molecular Weight:
3796.14
UNSPSC Code:
12352200
NACRES:
NA.32
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Thr-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
General description
Glucagon-like peptide 2 (GLP-2), an intestinal specific trophic hormone, is a gastrointestinal peptide with 33% sequence homology to glucagon. L-cells on the mucosa of the small intestine and colon release this enteroendocrine hormone.
Biochem/physiol Actions
Glucagon-like peptide 2 (GLP-2) plays a key role in the stimulation of intestinal epithelial proliferation. It possesses intestinotrophic endocrine/paracrine actions. GLP-2 is essentially a nutrition absorption regulator and an intestinal-specific trophic factor. It exhibits anti-inflammatory effects.
Glycogen-like peptide-2 (GLP-2) is involved in a range of processes in vivo including intestinal growth, reduction in bone breakage appetite and neuroprotection. GLP-2 human and GLP-2 rat may be used to study these and other processes.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
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Heather A Redstone et al.
Gastroenterology research and practice, 2010 (2010-10-19)
Background. Glucagon-like peptide 2 (GLP-2) is an intestinal specific trophic hormone, with therapeutic potential; the effects on intestinal healing are unknown. We used a rat model of colonic healing, under normoxic, and stress (hypoxic) conditions to examine the effect of
P L Brubaker et al.
Endocrinology, 138(11), 4837-4843 (1997-11-05)
Glucagon-like peptide-2 (GLP-2) has recently been identified as a stimulator of intestinal epithelial growth, prompting the development of RIA and HPLC methodologies to study this peptide in more detail. A GLP-2-specific antiserum (UTTH-7) was developed that recognizes amino acids 25-30
J Thulesen
Current protein & peptide science, 5(1), 51-65 (2004-02-18)
Glucagon-like peptide 2 (GLP-2) is a newly discovered gastrointestinal peptide with 33% sequence homology to glucagon. GLP-2 has attracted interest because of its potent intestinotrophic endocrine/paracrine actions. The peptide, consisting of 33-amino-acid, results from expression of the glucagon gene in
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