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Safety Information

SCP0148

Sigma-Aldrich

Furin Inhibitor II Peptide

≥95% (HPLC), lyophilized powder

Synonym(s):

Hexa-D-arginine amide

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About This Item

Empirical Formula (Hill Notation):
C36H75N25O6
Molecular Weight:
954.14
UNSPSC Code:
12352202
NACRES:
NA.32

Product Name

Furin Inhibitor II,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥48%

storage condition

protect from light

technique(s)

protein extraction: suitable

storage temp.

−20°C

Amino Acid Sequence

Mpa-Mpa-Mpa-Mpa-Mpa-Mpa

General description

Furin is a calcium-dependent serine endoproteinase and belongs to the subtilisin-like proprotein/prohormone convertase (PC) family. It is distributed ubiquitously and has a rhythmic movement between the trans-Golgi network, cell surface and the endosomes.

Application

Furin Inhibitor II has been used as a furin inhibitor:
  • to study its effects on transforming growth factor β1 (TGF-β1) induced glial cell line-derived neurotrophic factor (GDNF) production in non-tumorigenic immortalized human granulosa cell line (SVOG).
  • to study its effect on cleavage of (Pro) renin receptor (PRR) induced by bovine serum albumin (BSA) in human kidney 2 (HK-2) cells.
  • in furin cleavage assay.

Biochem/physiol Actions

Furin plays a role in processing several pro-proteins such as, bone morphogenetic protein 4 (BMP-4), insulin receptor and Notch1 receptor. It also processes human immune deficiency virus 1 (HIV-1) glycoprotein gp160, several metalloproteases and pro-β-nerve growth (pro-β-NGF) factor. Furin is also involved in cleaving transforming growth factor β1 (TGF-β1).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

动植物源性产品

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Certificates of Analysis (COA)

Lot/Batch Number
E278093
E257140
E1094
MI1170

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How can product SCP0148, Furin Inhibitor II, be dissolved?

    Product SCP0148, Furin Inhibitor II is soluble in water at 1 mg/ml.

  6. How can Product SCP0148, Furin Inhibitor II be dissolved?

    Product SCP0148, Furin Inhibitor II, is soluble in water at a concentration of 1 mg/mL.

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Jingwen Yin et al.
Cells, 9(1) (2020-01-16)
Glial cell line-derived neurotrophic factor (GDNF) is expressed at a high level in the human ovary and GDNF signaling is involved in the direct control of follicular activation and oocyte maturation. Transforming growth factor-β1 (TGF-β1) plays an important role in
Polyarginines are potent furin inhibitors
Cameron A, et al.
The Journal of Biological Chemistry, 275(47), 36741-36749 (2000)
Emily J Schepers et al.
The Journal of surgical research, 282, 118-128 (2022-10-23)
Glypican-3 (GPC3) is a surface-bound proteoglycan overexpressed in pediatric liver cancer and utilized clinically as an immunohistochemical tumor marker. Furin is a proprotein convertase that is ubiquitously expressed and shown to modify GPC3 post-translationally. In experimental models of epithelial-based cancers
C M Dubois et al.
The American journal of pathology, 158(1), 305-316 (2001-01-06)
Transforming growth factor (TGF)-beta1 plays an essential role in cell growth and differentiation. It is also considered as a gatekeeper of immune homeostasis with gene disruption leading to autoimmune and inflammatory diseases. TGF-beta1 is produced as an inactive precursor polypeptide
(Pro) renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro) renin receptor in renal epithelial cells
Fang H, et al.
American Journal of Physiology. Cell Physiology, 313(6), C632-C643 (2017)
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