SCP0133
Endomorphin II
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About This Item
Empirical Formula (Hill Notation):
C32H37N5O5
Molecular Weight:
571.67
NACRES:
NA.32
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Application
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, YPWF-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2, YPFF-NH2) are endogeneous opioid tetrapeptides with high affinity and specificity for the μ (mu) opioid receptor. Endomorphin-1 and 2 may be used to study the differential action and metabolism of these opioids.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jakub Fichna et al.
Pharmacological reviews, 59(1), 88-123 (2007-03-03)
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2) are two endogenous opioid peptides with high affinity and remarkable selectivity for the mu-opioid receptor. The neuroanatomical distribution of endomorphins reflects their potential endogenous role in many major physiological processes, which include perception of pain
Anna Janecka et al.
Peptides, 29(11), 2066-2073 (2008-08-23)
Centrally acting plant opiates, such as morphine, are the most frequently used analgesics for the relief of severe pain, even though their undesired side effects are serious limitation to their usefulness. The search for new therapeutics that could replace morphine
Yoshio Okada et al.
Vitamins and hormones, 65, 257-279 (2002-12-17)
Opioid peptides and their G-protein-coupled receptors (delta, kappa, mu) are located in the central nervous system and peripheral tissues. The opioid system has been studied to determine the intrinsic mechanism of modulation of pain and to develop uniquely effective pain-control
Javier Burgueño et al.
Scientific reports, 7(1), 15389-15389 (2017-11-15)
Compelling data in the literature from the recent years leave no doubt about the pluridimensional nature of G protein-coupled receptor function and the fact that some ligands can couple with different efficacies to the multiple pathways that a receptor can
Vijayalaxmi et al.
Fish physiology and biochemistry, 46(1), 429-438 (2019-11-30)
Endomorphins (EM-1 and EM-2) are the tetrapeptides involved in pain and neuroendocrine responses with a high affinity for μ-opioid receptors in vertebrates. However, their role in fish reproduction is not clear. The aim of this study was to investigate the
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