All Photos(1)
Synonym(s):
Ac-AEVD-pNA
Empirical Formula (Hill Notation):
C25H34N6O11
Molecular Weight:
594.57
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Acetyl-Ala-Glu-Val-Asp-p-Nitro-Anilide
Biochem/physiol Actions
The modified tetrapeptide Ac-AEVD-pNA, is a chromogenic substrate for caspase-10.
Regulatory Information
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S Kojio et al.
FEMS immunology and medical microbiology, 29(4), 275-281 (2000-12-19)
Caspase proteolytic activities, such as caspase-3, -2 and -6, of THP-1 human monocytic cells were markedly increased in a time- and dose-dependent manner by treatment with purified Shiga toxin 1 (Stx1) or Stx2. Caspase-3 activation was strictly correlated with internucleosomal
M Fujino et al.
International immunopharmacology, 1(11), 2011-2021 (2001-10-19)
FTY720, a novel immunosuppressive drug originally derived from a metabolite from Isaria sinclairii, is known to induce apoptosis in lymphocytes. In this study, we investigated the involvement of caspases and mitochondria in FTY720-mediated apoptosis using Jurkat cells, a human T
Vladislava Juric et al.
Molecular and cellular biology, 29(12), 3266-3279 (2009-04-15)
Although Fas ligand (FasL) is primarily expressed by lymphoid cells, its receptor Fas (CD95/Apo-1) is broadly expressed in numerous nonlymphoid tissues and can mediate apoptosis of parenchymal cells upon injury and infiltration of inflammatory cells. Here we show that CCN1
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