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SBR00015

Sigma-Aldrich

AEBSF Ready Made Solution

Synonym(s):

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H10FNO2S · HCl
CAS Number:
30827-99-7
Molecular Weight:
239.69
MDL number:
MFCD00132962
UNSPSC Code:
12352202
NACRES:
NA.85

Assay

≥97%

Quality Level

200

form

liquid

storage condition

protect from light

shipped in

dry ice

storage temp.

−20°C

SMILES string

F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

Application

This solution is provided at 100 mM in water. The stock solution may be diluted 1:100 for a 1 mM working concentration. Recommended concentrations for use are 0.1-1.0 mM.

Biochem/physiol Actions

AEBSF is a specific irreversible serine protease inhibitor. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. AEBSF is an excellent alternative to available serine protease inhibitors as it offers superior inhibitory activity and much lower toxicological risk.

Other Notes

The stability of AEBSF decreases rapidly at higher temperatures and at a pH greater than 7.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000374031
0000369440
0000318568
0000167886
0000188562

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Toru Hosoi et al.
European journal of pharmacology, 554(1), 8-11 (2006-11-18)
Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study
G Lunn et al.
Applied biochemistry and biotechnology, 48(2), 57-59 (1994-08-01)
Five enzyme inhibitors (phenylmethylsulfonyl fluoride, 4-amidinophenylmethanesulfonyl fluoride, 4-(2-aminoethyl)benzenesulfonyl fluoride, N alpha-p-tosyl-L-lysine chloromethyl ketone, and N-tosyl-L-phenylalanine chloromethyl ketone) in buffer, DMSO, or stock solutions were completely degraded by adding 1M NaOH and the final reaction mixtures were not mutagenic. The stability

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