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Sigma-Aldrich

Lipodisq® Styrene:Maleic Anhydride Copolymer 4:1

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UNSPSC Code:
12352202
NACRES:
NA.25

General description

This product is the anhydride form of the SMA Copolymer 4:1.

Application

Lipodisq reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents.

Functional pH range: 8.5 - 10.5

Legal Information

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

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Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8

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