SAB5703048
Anti-CD40 Antibody, clone 5V8X7, Rabbit Monoclonal
Synonym(s):
CD40,Bp50,CDW40,TNFRSF5,p50
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5V8X7, monoclonal
Application:
FACS
Citations:
-
form
liquid
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
5V8X7, monoclonal
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: 1:50 - 1:200
color
colorless
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CD40(958)
General description
This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Recombinant protein of human CD40
Application
FC
Storage Class
10 - Combustible liquids
wgk
WGK 2
Regulatory Information
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