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Merck
CN

SAB5702547

Anti-p38 MAPK Antibody, clone 2H9Q5, Rabbit Monoclonal

Synonym(s):

CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA

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About This Item

NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
2H9Q5, monoclonal
Application:
immunofluorescence
immunohistochemistry
western blot
Species reactivity:
human, rat, rat
Citations:
Technique(s):
immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:2000
Uniprot accession no.:
Q16539

Key Documents

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biological source

rabbit

conjugate

unconjugated

material

colorless

clone

2H9Q5, monoclonal

form

liquid

mol wt

40 kDa

species reactivity

human, rat, rat

concentration

0.4 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

immunogen sequence

NDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHY

UniProt accession no.

Q16539

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... MAPK14(1432)

Application

WB, IHC, IF/ICC

General description

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human p38 MAPK (Q16539).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Storage Class

10 - Combustible liquids

wgk

WGK 1

Regulatory Information

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