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Safety Information

SAB5701087

Sigma-Aldrich

Anti- HIF1α antibody produced in rabbit

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UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

antibody product type

primary antibodies

clone

polyclonal

form

liquid

species reactivity

mouse, human, rat

concentration

2.23 mg/mL

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HIF1A(3091)

General description

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Immunogen

Recombinant protein of human HIF1α.

Physical form

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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