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Safety Information

SAB5700602

Sigma-Aldrich

Anti-DDIT3/CHOP antibody produced in rabbit

Synonym(s):

C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, DDIT3, DDIT3 / CHOP, GADD153

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

19
 21

species reactivity

human, rat, mouse

concentration

4.62 mg/ml

technique(s)

immunofluorescence: 1:50-1:200
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

P35638

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DDIT3(1649)

Related Categories

General description

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human DDIT3 / CHOP (NP_004074.2).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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