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Key Documents

Safety Information

SAB5700569

Sigma-Aldrich

Anti-Phospho-ABL1-Y412 antibody produced in rabbit

Synonym(s):

ABL, ABL1, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, c-Abl, p150, v-abl

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

To inquire about this product SAB5700569, please contact your local Merck office or dealer. Contact Technical Service

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

123

species reactivity

rat, mouse, human

concentration

0.51mg/ml

technique(s)

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

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This Item
O4387MBD600911004760001
form

liquid

form

solution

form

suspension

form

-

usage

0.1 mL sufficient for 100 RT-PCR reactions

usage

0.1 mL sufficient for 100 RT-PCR reactions (as described in the Technical Bulletin for Product Codes HSRT100 and HSRT20)

usage

-

usage

sufficient for 50 labeling reactions

concentration

50 μM in H2O

concentration

70 μM in H2O

concentration

-

concentration

-

shipped in

wet ice

shipped in

wet ice

shipped in

-

shipped in

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

General description

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5′ end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

Immunogen

A phospho synthetic peptide corresponding to residues surrounding Y412 of human ABL1.

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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