SAB5300461
Monoclonal Anti-FOXP3 antibody produced in mouse
clone 2A11G9, ascites fluid
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Synonym(s):
AIID, IPEX, JM2, PIDX, XPID
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2A11G9, monoclonal
species reactivity
mouse, human
technique(s)
direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... Foxp3(50943)
General description
Forkhead box P3 (FOXP3) is located on human chromosome Xp11.23-Xq13.3. FOXP3 is a putative DNA-binding protein and is a member of the forkhead family. The protein is mainly expressed in the CD4+CD25+ regulatory T-cell subsets.
Immunogen
Purified recombinant fragment of human Foxp3 expressed in E.coli.
Mouse monoclonal antibody raised against Foxp3
Mouse monoclonal antibody raised against Foxp3
Application
Monoclonal Anti-FOXP3 antibody has been used in immunohistochemistry (IHC).
Biochem/physiol Actions
Forkhead box P3 (FOXP3) plays an essential role in the development of CD4+CD25+ regulatory T cells and regulates immune homeostasis. It also acts as a transcriptional repressor. Polyadenylation signal mutation of the gene leads to immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (IPEX). Abnormalities in the gene expression are also associated with the pathogenesis of autism spectrum disorders (ASD) and unexplained recurrent spontaneous abortion (URSA).
Physical form
Ascitic fluid containing 0.03% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
FOXP3 gene variations and susceptibility to autism: a case-control study
Safari, et al.
Gene, 596(6), 119-122 (2017)
Role of PIM2 in allergic asthma
Du Wei, et al.
Molecular Medicine Reports, 16(5), 7504-7512 (2017)
C L Bennett et al.
Immunogenetics, 53(6), 435-439 (2001-10-31)
The mouse scurfy gene, Foxp3, and its human orthologue, FOXP3, which maps to Xp11.23-Xq13.3, were recently identified by positional cloning. Point mutations and microdeletions of the FOXP3 gene were found in the affected members of eight of nine families with
Eleonora Gambineri et al.
Current opinion in rheumatology, 15(4), 430-435 (2003-06-24)
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX) is one of a group of clinical syndromes that present with multisystem autoimmune disease suggesting a phenotype of immune dysregulation. Clinically, IPEX manifests most commonly with diarrhea, insulin-dependent diabetes mellitus, thyroid disorders
Correlation between protein expression of FOXP3 and level of FOXP3 promoter methylation in recurrent spontaneous abortion
Hou Wenhui, et al.
Journal of Obstetrics and Gynaecology : The Journal of the Institute of Obstetrics and Gynaecology, 42(11), 1439-1444 (2016)
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