Anti-Akkermancia muciniphila antibody produced in rabbit

Akkermansia muciniphila is a Gram negative, oval shaped, non-motile, non-spore forming strictly anaerobic bacteria.1 A. muciniphila colonized in the mucus layer of the human intestine niche. A muciniphila inhabits the gastrointestinal tracts of most of healthy adults and represents 1-4% of the total fecal microbiota starting from early life.2 It is one of the top 20 most abundant species detectable in the human gut.3 It was found that A. muciniphila abundance in the gut was correlated to a healthy intestine and inversely correlated to many disease conditions.2 In comparison to healthy controls, A. muciniphila levels were low in intestinal disorders, such inflammatory bowel disease IBD, but also in other conditions, such as autism, atopy, and obesity.2,5-8 Therefore, A. muciniphila was suggested to serve as a marker of healthy intestine.
In addition, goring research identified A. muciniphila as a promising potential probiotic that can be administrated for the treatment of diseases such as, colitis, metabolic syndromes, immune diseases and cancer. However more research is needed to verify the safety of oral administration of A. muciniphila in humans.3

Anti-Akkermansia muciniphila antibody recognizes A. muciniphila lysate and whole dead bacteria.

A. muciniphila is able to degrade mucin, a key mucus component, using the enzymes sialidase and fucosidase, and utilize it as a source of carbon and nitrogen.2 Mucin degradation by A. muciniphila results in the production of short-chain fatty acids (SCFA), that become available metabolites to the host and also can stimulate the host immune system. Moreover, SCFA promotes the growth and metabolic activity of mucus- associated gut microbiota preventing the pathogenic bacteria from reaching the intestinal cells.4

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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