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Safety Information

SAB4200780

Sigma-Aldrich

Anti-Human IgM (μ-chain specific) antibody, Mouse monoclonal

clone MB-11, purified from hybridoma cell culture

Synonym(s):

Anti-Human immunoglobulin M

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5 MG
CN¥1,029.74

CN¥1,029.74

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5 MG
CN¥1,029.74

About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

CN¥1,029.74

Please contact Customer Service for Availability
Request a Bulk Order

biological source

mouse

Quality Level

300

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

MB-11, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

ELISA: 0.1-0.2 μg/mL using 2.5 μg/mL Human IgM myeloma for coating
immunoblotting: suitable

isotype

IgG2b

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sterility

sterile

sterility

sterile

sterility

non-sterile

sterility

non-sterile

manufacturer/tradename

Corning 4894

manufacturer/tradename

Corning 4830

manufacturer/tradename

Corning 4834

manufacturer/tradename

Corning 4826

material

natural tip, polypropylene

material

natural tip, polypropylene

material

natural tip, polypropylene

material

natural tip, polypropylene

packaging

rack of 96

packaging

rack of 96

packaging

rack of 96

packaging

rack of 96

volume range

0.1-10 μL

volume range

0.5-10 μL

volume range

0.5-10 μL

volume range

0.1-10 μL

General description

Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MB-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgM protein.
Immunoglobulin M (IgM) is the major class of surface immunoglobulins on lymphocyte membranes. IgM is suggested to act as the first line of defense during microbial infections. IgM has a pentameric structure, in which monomers are linking together via disulfide bonds. Surface IgM is expressed on immature and mature B cells, whereas IgM heavy chain is expressed intracellularly in pre-B cells. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation.

Specificity

Anti-Human IgM (m-chain specific) antibody, Mouse monoclonal specifically recognizes m chain of Human IgM. The antibody shows no cross-reactivity with human IgG, Fab, Fc, k, l, and g chains.

Immunogen

Purified human IgM

Application

The antibody is recommended to use in various immunological techniques, including ELISA and Immunoblot.

Biochem/physiol Actions

Immunoglobulin M (IgM) acts as an antigen specific part of the B cell antigen receptor on the surface of B lymphocytes that are not stimulated, in its monomeric form. Polymeric IgM molecules also serve as important activators of the classical complement cascade. IgM is essential in agglutination and cytolytic reactions. IgM serves as the antigen receptor of naive B cells and is involved in B cell maturation and complement activation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Other Notes

This product is for R&D use only, not for drug, household, or other uses.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000180348
    0000160925
    0000180348
    0000160925
    0000096855

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    G Vidarsson et al.
    Infection and immunity, 66(6), 2866-2870 (1998-05-29)
    Streptococcus pneumoniae is a major respiratory pathogen of infants, children, and the elderly. Polysaccharide vaccines have been useful in adult populations but do not elicit protective immunity in infants and young children. To enhance their immunogenicity, vaccines of pneumococcal polysaccharides

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