SAB4200743
Anti-Human IgG (Fc specific)-Peroxidase antibody, Mouse monoclonal
clone HP-6017, purified from hybridoma cell culture
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Synonym(s):
Anti-Immunoglubulin G (Fc specific)
UNSPSC Code:
12352203
NACRES:
NA.46
Recommended Products
biological source
mouse
Quality Level
conjugate
peroxidase conjugate
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
HP-6017, monoclonal
form
lyophilized powder
species reactivity
human
concentration
~2 mg/mL
technique(s)
ELISA: 1:80,000-1:160,000 using 5 μg/mL Human IgG myeloma for coating
isotype
IgG2a
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
Anti-Human IgG (Fc specific)-Peroxidase antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the HP-6017 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgG myeloma proteins covalently coupled to poly aminostyrene (PAS) microbeads. IgGs (Immunoglobulin G) are the most common Immunoglobulin′s isotype in blood, lymph, cerebrospinal and peritoneal fluids and serve as key players in the humoral immune response. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), consist of a variable Fab fragment (which includes the antibody recognition site) and a conserved Fc fragment.
Immunogen
Human IgG myeloma proteins
Application
Anti-Human IgG (Fc specific)-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions
IgG (Immunoglobulin G) deficiencies are often associated with various diseases. The Fc fragment has various important functions (e.g complement fixation, site for rheumatoid factor attachment and protein A binding) which indicate on the importance of immunoreagents specific for the Fc fragment of Human IgG.
Physical form
Supplied as a lyophilized powder.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
含少量动物源组分生物产品
Certificates of Analysis (COA)
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R Jefferis et al.
Immunology letters, 10(3-4), 223-252 (1985-01-01)
Seventy-four monoclonal antibodies (McAb) of putative specificity for human IgG (11), the IgG sub-classes (59) or Gm allotypes (4) have been evaluated for reactivity and specificity in eight laboratories employing different assay techniques or protocols. For the IgG, IgG3, IgG4
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These
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