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Safety Information

SAB4200734

Sigma-Aldrich

Anti-IL6 high affinity antibody, Mouse monoclonal

clone IL6-2A3, purified from hybridoma cell culture

Synonym(s):

Anti-B-cell stimulatory factor 2 (BSF-2), Anti-CTL differentiation factor (CDF), Anti-Hybridoma growth factor, Anti-Interferon beta-2 (IFN-beta-2), Anti-Interleukin-6

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5 MG
CN¥1,978.95
25 MG
CN¥6,372.41

CN¥1,978.95

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5 MG
CN¥1,978.95
25 MG
CN¥6,372.41

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CN¥1,978.95

Please contact Customer Service for Availability

biological source

mouse

Quality Level

200

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

IL6-2A3, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

ELISA: suitable
immunoblotting: 0.125-0.25 μg/mL using recombinant human IL6 expressed in HEK-293T cells
immunoprecipitation (IP): 10-20 μg/test using concentrated supernatant of human osteosarcoma MG-63 cells treated with IL1β

isotype

IgG2a

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packaging

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manufacturer/tradename

Milliflex®

manufacturer/tradename

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manufacturer/tradename

Milliflex®

technique(s)

Rapid Sterility Testing: suitable

technique(s)

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technique(s)

Rapid Sterility Testing: suitable

technique(s)

Rapid Sterility Testing: suitable

application(s)

bioburden testing
pharmaceutical
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bioburden testing
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General description

Interleukin-6 (IL6) is a multifunctional cytokine.

Immunogen

recombinant human IL6

Application

Anti-IL6 high affinity antibody, Mouse monoclonal has been used in
  • immunoblotting
  • immunoprecipitation
  • ELISA

Biochem/physiol Actions

Interleukin-6 (IL6) plays a wide variety of important biological roles in the immune, nervous and endocrine system. It is an essential component for hybridoma growth and is found in many supplemental cloning media. IL6 regulates acute and chronic inflammatory diseases and has been proven to be an excellent target for clinical treatment against autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis and Castleman′s disease. IL6 also plays a key role in the pathogenesis of multiple myeloma.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000334308
    0000334308
    0000249522
    0000249522
    017M4831V

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    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    Ishihara K and Hirano T
    Cytokine & Growth Factor Reviews, 13(4-5), 357-368 (2002)
    A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
    Voorhees PM, et al.
    British Journal of Haematology, 161(3), 357-366 (2013)

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