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Merck
CN

SAB4200693

Anti-CNPase antibody, Mouse monoclonal

clone 11-5B, purified from hybridoma cell culture

Synonym(s):

2′,3′-cyclic-nucleotide 3′-phosphodiesterase, CNP, CNPase

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-CNPase antibody, Mouse monoclonal, clone 11-5B, purified from hybridoma cell culture

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

11-5B, monoclonal

form

buffered aqueous solution

mol wt

antigen 46 kDa (CNP1)
 48 kDa (CNP2)

species reactivity

pig (pig origin but not guinea pig), sheep, rat, bovine, rabbit, canine, human, mouse

concentration

~1 mg/mL

technique(s)

immunoblotting: 5-10 μg/mL using whole rat brain extract

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CNP(1267)

Application

Anti-CNPase antibody, Mouse monoclonal has been used in immunoblotting, immunohistochemistry.

Biochem/physiol Actions

CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), interacts with cytoskeletal proteins, cholesterol-rich cell membranes, nucleotides and various other proteins. Abnormalities in CNPase expression cause perturbations in myelin structure and are associated with neurological diseases such as schizophrenia and multiple sclerosis. It was shown that CNPase can bind Gag structural protein and prevent the assembly of HIV-1 particle, demonstrating the anti-viral activity of CNPase.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-CNPase antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the 11-5B hybridoma produced by the fusion of mouse myeloma cells and splenocytes from RBF/Dn mouse immunized with human 2α,3α-cyclic nucleotide 3α-phosphodiesterase. CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), also known as CNP, is a membrane-anchored enzyme within the myelin sheath. CNPase is primarily a heterodimer of approximately 94 kDa. The heterodimer consists of a varied proportion of CNPase isoforms CNP1 (46 kDa) and CNP2 (48 kDa).

Immunogen

Human 2′,3′-cyclic nucleotide 3′-phosphodiesterase

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
026M4857V

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2', 3'-cyclic nucleotide 3'-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.
Sprinkle T J.
Critical Reviews in Neurobiology, 4(3), 235-301 (1989)
Inhibition of HIV-1 particle assembly by 2?, 3?-cyclic-nucleotide 3?-phosphodiesterase
Wilson S J, et al.
Cell host & microbe, 12(4), 585-597 (2012)
2?, 3?-cyclic nucleotide phosphodiesterase (CNPase) as a target in neurodegenerative diseases
Baburina Y L, et al.
Neurochemical Journal, 7(1), 1-15 (2013)
Lin Chen et al.
Frontiers in aging neuroscience, 12, 590530-590530 (2020-11-17)
Running exercise, one of the strategies to protect brain function, has positive effects on neurons and synapses in the cortex and hippocampus. However, white matter, as an important structure of the brain, is often overlooked, and the effects of long-term
Activation of cannabinoid type 1 receptor (CB1) modulates oligodendroglial process branching complexity in rat hippocampal cultures stimulated by olfactory ensheathing glia-conditioned medium.
Paes-Colli, et al.
Frontiers in Cellular Neuroscience, 17, 1134130-1134130 (2023)
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