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Merck
CN

SAB4200617

Monoclonal Anti-Myb antibody from mouse

clone MB-8, purified immunoglobulin

Synonym(s):

Proto-oncogene c-Myb, Transcriptional activator Myb, Transcriptional activator Myb; Proto-oncogene c-Myb

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Monoclonal Anti-Myb antibody from mouse, clone MB-8, purified immunoglobulin

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MB-8, monoclonal

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

flow cytometry: 2.5-5 μg/test using using HL-60 cells.
immunoblotting: 0.5-1 μg/mL using using Jurkat total cell extract.
immunofluorescence: 2-4 μg/mL using using HeLa cells.

isotype

IgG1

UniProt accession no.

P10242

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... MYB(4602)

Application

Monoclonal Anti-Myb antibody from mouse may be used in:
  • immunoblotting
  • flow cytometry
  • immunocytochemistry

Biochem/physiol Actions

MYB is a transcription factor that regulates stem and progenitor cells in the bone marrow, colonic crypts and a neurogenic region of the adult brain. Loss of MYB activity in these cells leads to severe or lethal phenotypes. MYB is an oncogene and is observed in some human leukemias. In addition, It is also observed that MYB is activated in colon and breast cancer.
Monoclonal Anti-Myb recognizes human and mouse Myb.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Myb (mouse IgG1 isotype) is derived from the hybridoma MB-8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. MYB proto-oncogene, transcription factor is encoded by the gene mapped to human chromosome 6q23.3.

Immunogen

synthetic peptide corresponding to a sequence at the N-terminal region of human Myb.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For extended storage, freeze at -20 ˚C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
054M4770V
054M4770V

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The HBS1L-MYB intergenic region on chromosome 6q23. 3 influences erythrocyte, platelet, and monocyte counts in humans
Menzel S, et al.
Blood, 110(10), 3624-3626 (2007)
MYB function in normal and cancer cells
Ramsay RG, et al.
Nature Reviews. Cancer, 8, 523-534 (2008)

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