SAB4200593
Anti-Occludin antibody from rabbit
affinity isolated antibody
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All Photos(3)
Synonym(s):
BLCPMG, OCLN, PPP1R115
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
species reactivity
human
technique(s)
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... OCLN(100506658)
Related Categories
General description
Occludin (OCLN) is an integral membrane protein, encoded by the gene mapped to human chromosome 5q13.2. OCLN is a ~65 kDa protein with four transmembrane domains including, a long COOH-terminal cytoplasmic domain, a short NH2-terminal cytoplasmic domain, two extracellular loops, and one intracellular turn. It is specifically localized at tight junctions (TJ).
Application
Anti-Occludin antibody from rabbit has been used in immunocytochemistry and western blotting.
Biochem/physiol Actions
Occludin (OCLN), along with tight junction (TJ)-associated peripheral membrane proteins, plays a vital role in formation and regulation of TJ. The encoded protein facilitates the translocation of p85a to TJs to regulate actin organization after oxidative stress. OCLN is also implicated in cell migration. Mutation in the gene leads to the development of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin.
Mikio F, et al.
The Journal of Cell Biology, 141(7), 1539?1550-1539?1550 (1998)
Recessive Mutations in the Gene Encoding the Tight Junction Protein Occludin Cause Band-like Calcification with Simplified Gyration and Polymicrogyria.
Mary C O, et al.
American Journal of Human Genetics, 87(3), 354?364-354?364 (2010)
Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry.
Kohaar I, et al.
Journal of Virology, 84(14), 6987-6994 (2010)
The tight junction protein, occludin, regulates the directional migration of epithelial cells.
Du D, et al.
Developmental Cell, 18(1), 52-63 (2010)
Dongli Li et al.
Stem cell research & therapy, 12(1), 24-24 (2021-01-09)
Subretinal fibrosis resulting from neovascular age-related macular degeneration (nAMD) is one of the major causes of serious and irreversible vision loss worldwide, and no definite and effective treatment exists currently. Retinal pigmented epithelium (RPE) cells are crucial in maintaining the
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