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Merck
CN

SAB4200588

Anti-CHD1 (C-terminal) antibody from rabbit

affinity isolated antibody

Synonym(s):

ATP-dependent helicase CHD1, chromodomain helicase DNA binding protein 1

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-CHD1 (C-terminal) antibody from rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 2.5-5.0 μg/mL using whole extracts of mouse P19 cells.
immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells.

UniProt accession no.

O14646

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... CHD1(1105)
mouse ... Chd1(12648)

Application

Anti-CHD1 (C-terminal) antibody from rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Chromodomain-helicase-DNA-binding protein 1 (CHD1) modifies chromatin structure affecting the interaction of transcriptional apparatus to its chromosomal DNA template. CHD1 is required for maintaining open chromatin and pluripotency in embryonic stem cells (ESCs).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor. The CHD family of proteins contains two domains : chromo (chromatin organization modifier) and SNF2-related helicase/adenosine triphosphatase (ATPase).

Immunogen

synthetic peptide corresponding to the C-terminal region of human CHD1 , conjugated to KLH.

Physical form

a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
083M4805V
083M4805

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Concetta G A Marfella et al.
Mutation research, 618(1-2), 30-40 (2007-03-14)
Chromatin remodeling enzymes contribute to the dynamic changes that occur in chromatin structure during cellular processes such as transcription, recombination, repair, and replication. Members of the chromodomain helicase DNA-binding (Chd) family of enzymes belong to the SNF2 superfamily of ATP-dependent
Lena Ho et al.
Nature, 463(7280), 474-484 (2010-01-30)
New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in

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