SAB4200565
Monoclonal Anti-ZFP36/TTP antibody produced in mouse
clone TTP6, tissue culture supernatant
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Synonym(s):
Anti-G0/G1 switch regulatory protein 24, Anti-G0S24, Anti-Growth factor-inducible nuclear protein NUP475, Anti-NUP475, Anti-RNF162A, Anti-TIS11, Anti-TIS11A, Anti-Zinc finger protein 36 homolog, Anti-tristetraprolin, Anti-zinc finger protein 36, C3H type, homolog (mouse), Anti-zinc finger protein, C3H type, 36 homolog (mouse)
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
TTP6, monoclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa
species reactivity
mouse, bovine, rat, dog, human, monkey
technique(s)
western blot: 1:4,000-1:8,000 using extracts of HepG2 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ZFP36(7538)
General description
Monoclonal Anti-ZFP36/TTP (mouse IgM isotype) is derived from the hybridoma TTP6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide corresponding to an internal sequence of human ZFP36/TTP, conjugated keyhole limpet hemocyanin (KLH). ZFP36 (also known as tristetraprolin or TTP) is a RNA-binding protein. It belongs to the RNA-binding zinc-finger protein family. TTP consists of a cysteine-cysteine-cysteine-histidine (CCCH) zinc finger motif and uridine-rich elements (AREs) in the 3′ untranslated region (3′ UTR) of target mRNA. This gene is located on human chromosome 19q13.1.
Immunogen
a peptide corresponding to an internal sequence of human ZFP36/TTP conjugated KLH.
Application
Monoclonal Anti-ZFP36/TTP antibody has been used in immunoblotting.
Biochem/physiol Actions
ZFP36 (also known as tristetraprolin or TTP) participates in controlling the expression of AU-rich element (ARE) -containing mRNAs. It participates in accelerating mRNA decay. ZFP36 was found to limit the expression of a number of critical genes frequently overexpressed in inflammation and cancer. It also plays a major role in differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis and immunity.
Physical form
Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Regulatory Information
含少量动物源组分生物产品
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Tristetraprolin: A novel target of diallyl disulfide that inhibits the progression of breast cancer
Xiong T, et al.
Oncology Letters, 15(5), 7817-7827 (2018)
The RNA binding protein tristetraprolin down-regulates autophagy in lung adenocarcinoma cells
Dong F, et al.
Experimental Cell Research, 367(1), 89-96 (2018)
The role of RNA-binding protein tristetraprolin in cancer and immunity
Guo J, et al.
Medical Oncology (Northwood, London, England), 34(12), 196-196 (2017)
ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity
Moore MJ, et al.
eLife, 7, e33057-e33057 (2018)
The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin
Wu X, et al.
PLoS Genetics, 14(5), e1007366-e1007366 (2018)
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